Nancy Wyllie holds Master's degrees from RISD and Tulane University in New Orleans. She studied film at New York University following completion of Graduate School. She has exhibited her photo-based work in New York at White Columns, The Alternative Museum, Artists's Space, Exit Art and P.P.O.W., as well as Brandeis University, Ohio State University, Marymount Manhattan College, Providence College and  M.I.T.
Her video art has been screened throughout the US and abroad including The Whitney Museum of American Art at Altria, The 7th International Berlin Director's Lounge and the Persona Art Festival in London where she won the Persona Award in 2011. In December 2011, her video short titled, "Nothing," was one of 25 international selections screened at Tribeca Cinemas Video Art & Experimental Film Festival in New York. In October 2012, "Layover" premiered at Cinema Reset : Multimedia & Experimental Cinema Exhibition at the Contemporary Arts Center, New Orleans Film Festival. In 2013 , three experimental videos were selected for inclusion in Film Reel Screenings, Queens Hall Gallery, Narbeth, Wales and at Colony 13, Cardigan, Wales, UK.  Her experimental short documentary titled, "Moth Vitals" was included in Films About Workers, Antenna Gallery, French Quarter, New Orleans with Harvard's Sensory Ethnography Lab and LA's video collective Freewaves. In 2014, "Exit Strategy : Education Behind Bars" was screened at Violence Transformed, Massachusetts State House, Boston, at Cambridge College and the Resnikoff Gallery. She was one of four American experimental filmmakers screened at the 2015 Venice Experimental Cinema and Performance Art Festival. Wyllie's work in experimental cinema is featured in a 12 page interview in the Biennale Edition of VideoFocus, a special issue featuring video artists and independent filmmakers. She is one of 15 filmmakers selected from over 3000 international submissions by Sitgmart 10 panelists in France, Italy and Germany.

"Moth Vitals" was nominated for Best Cinematography and Best Sound  (Winner) in a Short Documentary at the Portsmouth International Film Festival, UK Sept 2015. "Moth Vitals" was one of 15 international films selected for screening at the As iFF International Film Festival, NY Nov 13, 2015. "Reenactments" was included in the 11th Annual FILMIDEO at The Newwark Museum. In June 2016 "Moth Vitals" was   screened at The New Media Film Festival at The Landmark Theater, Los Angeles (LA Premiere) and at TAFFNY The Americas Film Festival New York. "Moth Vitals" was screened in November 2016 at The Aesthetica Film Fesitval in York, UK, a BAFTA Qualifying festival. Wyllie was a Panel Member in a Discussion led by Greg McGee at ASFF in York, UK on November 4, 2016. 'Moth Vitals' was one of 28 international submissions selected for screening at NOW & AFTER International Video Art Festival at The Darwin Museum in Moscow. The State Darwin Museum made "Moth Vitals" part of their Permanent Collection in November 2016. Her gun control film 'Reenactments" won The Americas Award for Best Experimental Film at The Americas Film Festival New York 2018. TAFFNY is organized by the Division of Interdiscilpinary Studies at CUNY. 'Inquest" is one of 32 international selections that is included at Venice Film Week 2019. 'Inquest' will also screened at Brigade des Images  2019 Paris, espace Shakirail and at Murze Film Festival Murze Magazine Interview 7th edition.
'Soaked Earth' premiered at Extrmemely Shorts Film Festival 2020, Houston Meda Arts Aurora Picure Show. Her short film 'Inquest' screened at MicroMania Film Festival 2020 /Buffalo Rising. 'Cover to Cover,' an experimental short about Marilyn Monroe's library had its European Premiere at the Unrestricted View Film Festival in London, July 2020.
Wyllie is a retired Professor of Art & Digital Media at The Community College of Rhode Island.