Nancy Wyllie holds Master's degrees from RISD and Tulane University in New Orleans. She studied film at New York University following completion of Graduate School. She has exhibited her photo-based work in New York at White Columns, The Alternative Museum, Artists's Space, Exit Art and P.P.O.W., as well as Brandeis University, Ohio State University, Marymount Manhattan College, Providence College and  M.I.T.

Her video art has been screened throughout the US and abroad including The Whitney Museum of American Art at Altria, The 7th International Berlin Director's Lounge and The Newark Museum.  In December 2011, her video short titled, "Nothing," was one of 25 international selections screened at Tribeca Cinemas Video Art & Experimental Film Festival in New York. In October 2012, "Layover" premiered at Cinema Reset : Multimedia & Experimental Cinema Exhibition at the Contemporary Arts Center, New Orleans Film Festival.  

Her experimental short documentary titled, "Moth Vitals" was included in Films About Workers, Antenna Gallery, French Quarter, New Orleans with Harvard's Sensory Ethnography Lab and LA's video collective Freewaves. In 2014, "Exit Strategy : Education Behind Bars" was screened at Violence Transformed, Massachusetts State House, Boston, at Cambridge College and 'Arts in Prison: Sharing Global and Loclal Practices' at Brown University.  She was one of four American experimental filmmakers screened at the 2015 Venice Experimental Cinema and Performance Art Festival. Wyllie's work in experimental cinema is featured in a 12 page Stigmart interview in the Biennale Edition of VideoFocus, a special issue featuring video artists and independent filmmakers. She is one of 15 filmmakers selected from over 3000 international submissions by Sitgmart 10 panelists in France, Italy and Germany.

"Moth Vitals" was among 15 international films selected for screening at the As iFF International Film Festival, NY, 2015. The film also screened at The New Media Film Festival at The Landmark Theater, Los Angeles (LA Premiere), at TAFFNY The Americas Film Festival New York in November 2016, at ASFF The Aesthetica Film Festival in York, UK, a BAFTA Qualifying festival. Wyllie was a Panel Member in a Discussion led by Greg McGee at ASFF in York, UK on November 4, 2016.
'Moth Vitals' was one of 28 international submissions selected for screening at NOW & AFTER International Video Art Festival at The Darwin Museum in Moscow. The State Darwin Museum made 'Moth Vitals' part of their Permanent Collection in November 2016.

Her gun control film 'Reenactments" won The Americas Award for
Best Experimental Film at The Americas Film Festival New York 2018. TAFFNY is organized by the Division of Interdiscilpinary Studies at CUNY. The Awards Ceremony took place at the Smithsonian National Museum of the American Indian on June 15, 2018.

'Inquest" was one of 32 international selections that is included at Venice Film Week 2019'Inquest'  also screened at Brigade des Images  2019 Paris, espace Shakirail and at Murze Film Festival with accompanying  Murze Magazine Interview 7th edition and at Micromania Film Festiva 2020l / Buffalo Rising.

'Soaked Earth' premiered at Extremely Shorts Film Festival 2020, Houston Meda Arts Aurora Picure Show.

'Moth Vitals’ screened at 2020 Jellyfest film festival at the AFI /American Film Institute, Los Angeles. Also in 2020, ‘Inquest’ was selected for the Blow-up International Arthouse Film Festival, Chicago, IL. USA. ‘Soaked Earth’ received Honorable mention for Best Experimental at the SENE Film Festival 2021 with an LA Premiere at the Super Shorts Los Angeles Film Festival at the Lee Strasberg Theater and Film Institute in December 2021.

'Cover to Cover,' an experimental short about Marilyn Monroe's library, had its European Premiere at the Unrestricted View Film Festival in London, July 2020 and sreened at the IPFF International Portrait Film Festival in Sophia, Bulgaria Novemver 2022.

'Soaked Earth' screened at the New York Short Film Festival, Cinema Village, November 2022.

Her film project exposing the underbelly of the global skin bleaching epidemic titled, “Getting Under Our Skin” was funded by The Puffin Foundation and screened at The Torpedo Factory in Through These Eyes July- September 2022. 'Twenty Sqaure Feet' was a Nominee at the New York Independent Cinema Awards and was an Award Winner at Accolade Global Film Competition in 2023.

Wyllie taught foundation art & design, digital media courses and video art at Ithaca College, RISD, Vermont College of Norwich University (MFA faculty) and at CCRI until 2018. She is currently a full time filmmaker.